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Quantification Challenges of Chromatin — Associated Host Cell DNA:
An Underestimated Risk

  • Discover why host cell DNA quantities are often significantly underestimated.
  • Understand the limitation of conventional nucleases when degrading chromatin

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The Largest Overlooked Cost Driver in Viral Vector Production

  • Up to half of produced vector is lost during Down Stream Processing(DSP)
  • The majority of manufacturing cost accumulates is DSP raw materials
  • Nuclease design decisions determine downstream economics

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Amplification
Contamination Control
DNA Modification
Metagenomics
PCR Clean-up
RNA Manufacturing
Sample Prep & Clean-up
Viral Vector Analytics
Viral Vector Production
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Showing 7 resource

WEB

August 28, 2026
Application Note
Molecular Diagnostics

Carry-Over Contamination Control in One-Step RT-qPCR

Prevent carryover contamination in one-step RT-PCR without compromising cDNA synthesis. Learn how Cod UNG enables effective contamination control and reliable assay performance.

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WEB

April 23, 2026
Application Note
Advanced Therapies
Reducing Immunogenic DNA in Viral Vector Production to Improve in vivo Results

Reducing Immunogenic DNA in Viral Vector Production to Improve in vivo Results

Host-cell DNA contamination confounds results and reduces quality. Salt-active nucleases remove it at lysis, improving consistency and data reliability.

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WEB

May 12, 2025
Application Note
Molecular Diagnostics
Host Cell DNA Depletion

Host Cell DNA Depletion Prior to Diagnostic Metagenomic Analysis

Efficient host-DNA depletion with salt-active nucleases turns metagenomics into a same-day, pan-pathogen diagnostic tool—see how.

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WEB

August 23, 2023
Application Note
Advanced Therapies
Viral Vector Bioprocessing

Viral Vector Bioprocessing

Our nucleases are, especially salt tolerant and tailor made for viral bioprocessing, which results in a less expensive and more efficient process.

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WEB

August 23, 2023
Application Note
Molecular Diagnostics
PCR Carry-Over Prevention

Carry-Over Contamination Control and Amplicon Preservation in Standard PCR

To prevent PCR carry-over, the PCR mixture is treated with uracil DNA glycosylase (UNG).

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WEB

August 23, 2023
Application Note
Molecular Diagnostics
Isothermal Amplification

Isothermal Amplification

IsoPol™BST⁺ is well suited for isothermal applications such as LAMP and RT-LAMP for its superior amplification performance and robustness.

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WEB

March 20, 2026
Webinar
Advanced Therapies

Your Viral Vector Analytics May Not Reflect Process Reality

How Analytical Sample Preparation Can Create False Confidence in Viral Vector Manufacturing

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WEB

September 2, 2025
Webinar
Molecular Diagnostics

Unified Metagenomic Method for Rapid Detection of Microorganisms in Clinical Samples

All classes of pathogen ID. All in one tube. Under 7 hours.

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WEB

April 29, 2024
Webinar
Advanced Therapies

Can you truly optimize your bioprocessing without knowing THIS about DNA vs Chromatin?

The fragment problem you likely have and don't even know It

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WEB

April 29, 2024
Webinar
Advanced Therapies

The Art and Science of Removing DNA from Viral Vectors, Oncolytic Viruses and Vaccines

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WP

August 3, 2026
White Paper
Advanced Therapies

Efficient Chromatin Removal in Viral Vector Manufacturing using Salt-Active Nucleases

Efficient chromatin removal can simplify downstream processing, improve purity, reduce costs, and support viral vector manufacturing.

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WP

June 29, 2026
White Paper
Advanced Therapies

The Largest Overlooked Cost Driver in Viral Vector Production

Why your nulease strategy determines yield, quality and cost per dose

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VID

June 12, 2026
Video
Advanced Therapies

The Hidden Cost of Poor DNA Clearance in Viral Vector Manufacturing

DNA clearance is a critical factor in viral vector manufacturing, influencing downstream processing efficiency, vector recovery, product purity, and overall manufacturing economics

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PSTR

October 15, 2026
Poster
Advanced Therapies

mRNA cap-efficiency sample prep From 6 hours to <30 minutes

Simplify mRNA cap-efficiency analysis with RiboCleave™ 1. See how sample preparation is reduced from approximately 6 hours to 30 minutes.

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PSTR

October 15, 2026
Poster
Advanced Therapies

Post-IVT template DNA removal with up to 10x fewer enzyme units

See how RiboClean™ dsDNase removes post-IVT template DNA with up to 10× fewer enzyme units while maintaining RNA integrity and yield.

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PSTR

July 27, 2026
Poster
Advanced Therapies
DNA fragment size determination

DNA fragment size determination: Are electrophoresis-based methods capable of detecting chromatin?

Learn why electrophoresis may underestimate chromatin-associated DNA. Download the ACIB research poster.

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PSTR

July 27, 2026
Poster
Advanced Therapies
Purification of Measles Virus using Salt-active Nuclease

Purification of Measles Virus by Combination of Salt-active Nuclease Treatment and Heparin Affinity Chromatography

Download an ACIB research poster exploring the use of M-SAN treatment and heparin-affinity chromatography for measles virus purification.

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PSTR

July 17, 2026
Poster
Advanced Therapies

Endonuclease Treatment in Downstream Processing of Virus-Like Particles

Download the ACIB scientific poster showing how salt-active nucleases improve chromatin removal, VLP purity, and DSP efficiency.

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PSTR

July 17, 2026
Poster
Advanced Therapies

Quantification Challenges of Chromatin — Associated Host Cell DNA: An Underestimated Risk

Discover how chromatin can mask true host-cell DNA levels and why effective nuclease treatment is critical for bioprocessing.

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PSTR

June 29, 2026
Poster
Advanced Therapies

The Largest Overlooked Cost Driver in Viral Vector Production

The hidden cost driver in viral vector production: how nuclease strategy affects chromatin clearance, yield, and COGS.

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USER

June 26, 2026
User Guides
Advanced Therapies

SAN HQ User Guide

SAN HQ user guide for DNA and chromatin clearance in high-salt bioprocessing workflows, with protocols to improve purity, yield and downstream performance.

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USER

June 26, 2026
User Guides
Advanced Therapies

M-SAN HQ User Guide

M-SAN HQ user guide for DNA and chromatin clearance under physiological conditions, with protocols to support viral vector bioprocessing workflows.

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INFO

September 21, 2026
Infographics
Molecular Diagnostics

Why do you need a heat labile UDG?

Learn why heat-labile UDG is essential for RT-qPCR and PCR workflows. Discover how reliable enzyme inactivation prevents carryover contamination.

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INFO

August 17, 2026
Infographics
Advanced Therapies

Smarter Cleanup for Lentiviral Manufacturing

Learn how host cell DNA and chromatin can impact lentiviral production, and why effective early removal is critical for process efficiency, purification performance, and vector yield.

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