Improve DNA and Chromatin Clearance in AAV Manufacturing
Residual DNA in AAV manufacturing is not always what it seems. Chromatin-bound DNA can remain hidden from detection, while aggregation and high-salt conditions can make effective DNA removal more challenging. The infographic compares different approaches to DNA removal and shows how they affect DNA clearance, aggregation and process complexity.
Download to learn:
- Why chromatin-bound DNA can be underestimated during AAV manufacturing
- How salt and chromatin affect DNA removal and detection
- How different nuclease strategies compare for DNA and chromatin clearance
- Considerations for simplifying DNA removal into a more efficient process
Looking for a more effective approach to DNA and chromatin removal?
Learn how SAN HQ supports efficient DNA and chromatin digestion in viral vector manufacturing.
