Your Viral Vector Analytics May Not Reflect Process Reality
details
Your DNA analytics may be giving you confidence in a sample that no longer reflects your actual process conditions.
Many standard chromatin analysis workflows were adapted from molecular biology, where sample preparation steps are intentionally used to break apart chromatin before measurement. That improves DNA accessibility and detectability during analysis.
But in viral vector manufacturing, chromatin exists under very different conditions.
The result is a potentially critical mismatch: The chromatin measured analytically may not fully reflect the chromatin your downstream process actually has to remove.
New data from ACIB, publishing Summer 2026, shows the consequences showing up downstream — often disguised as something else entirely.
This webinar brings together scientists from ACIB and ArcticZymes to show you what the data reveals — and what to do about it.
What you will learn
- Why analytical sample preparation can fundamentally change chromatin before measurement
- How inherited molecular biology workflows may create blind spots in bioprocessing analytics
- Why apparently acceptable DNA results may not reflect downstream process reality
- How chromatin can impact filtration, purification efficiency, aggregation, and DSP performance
- Why nuclease performance can appear very different analytically versus operationally
- New insights from ACIB into process-relevant chromatin detection in viral vector manufacturing
- Practical considerations for aligning analytics more closely with real process conditions.
Who should attend
This webinar is designed for scientists and technical leaders working in viral vector manufacturing who rely on DNA analytics to make process decisions — including process development scientists, downstream and purification scientists, CMC teams, and manufacturing leads at CDMOs and gene therapy companies.
This is the session your DNA clearance data has been waiting for.
If you have ever seen unexplained variability in your DSP performance, questioned whether your DNA clearance data truly reflects what is in your sample, or struggled to achieve consistent yields across batches, this session is directly relevant to your work.
About the collaboration
This webinar is based on peer-reviewed research conducted at ACIB, one of Europe's leading industrial biotechnology research institutes, in collaboration with ArcticZymes Technologies, the inventor of salt-active nucleases for biomanufacturing. Together, they have published independent, reproducible data showing how chromatin behaves in viral vector harvests, how standard nucleases fail to remove it, and what optimized nuclease strategies deliver in practice.
About acib:
The Austrian Centre of Industrial Biotechnology (acib) is a non-profit international research centre in the field of industrial biotechnology. The centre develops sustainable, and economically and technologically advanced processes for the biotech-, pharmaceutical and chemical industries.
About ArcticZymes:
ArcticZymes is the inventor Salt Active Nucleases (2015) and is the only provider of nucleases that perform optimally at both physiological and high-salt conditions. Our unique Biomanufacturing portfolio focuses on solutions that empower you to choose the nuclease that performs best, based on your conditions and your process. Learn more about ArcticZymes: https://www.arcticzymes.com/about-us
Speakers
Patricia Pereira Aguilar
Patricia Pereira Aguilar, Ph.D., is Senior Scientist at the Austrian Centre of Industial Biotechnology (acib) and affiliated to the Institute of Bioprocess Sciences and Enginnering at the BOKU University, Vienna, Austria. In 2020, she completed her Ph.D. degree in “Biomolecular Technology of Proteins” (BioTop) at BOKU, under the supervision of Professor Alois Jungbauer. After that she started working as a Postdoctoral Researcher at acib and since January 2024 as a Senior Scientist and Research Group Lead. Her research focus on the development of downstream processes and analytical tools for enveloped bionanoparticles for vaccine and gene therapy applications, such as virus-like particles, viruses and extracellular vesicles.
Viktoria Mayer
Viktoria Mayer, Dr. is Post Doc at the Austrian Centre of Industial Biotechnology (acib) in Vienna, Austria. In 2019, she completed her M.Sc. degree in Biotechnical Processes at the University of Applied Sciences in Tulln. After that she started working as a PhD student at acib which she finished in December 2024. Her research focuses on bionanoparticle downstream processing and analytics especially for viruses and virus-like particles.
Jørn Remi Henriksen
Jørn Henriksen, Ph.D., works with Scientific Content & Application Insights at ArcticZymes. With a deep foundation in molecular biology, Jørn Henriksen brings extensive expertise in enzyme technologies to the evolving field of metagenomic diagnostics. His focus is on bridging complex biochemical mechanisms with real-world clinical utility — supporting researchers and clinicians in optimizing workflows for clearer, faster pathogen detection. At ArcticZymes Technologies, Jørn plays a key role in translating scientific insights into tools that improve diagnostic accuracy and efficiency.
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