The Hidden Cost of Poor DNA Clearance in Viral Vector Manufacturing

In this video, we explore how nuclease strategy can impact the removal of residual host cell DNA and why it may play a larger role in process performance than many manufacturers realize.

Learn how effective DNA clearance can help:

✅ Improve vector recovery
✅ Reduce downstream processing bottlenecks
✅ Increase product purity
✅ Improve process consistency
✅ Reduce nuclease consumption
✅ Lower manufacturing costs

Lionel Malbec, Senior Product Manager at ArcticZymes Technologies, discusses the challenges associated with chromatin digestion and residual DNA removal in viral vector production, including the impact on filtration, chromatography performance, yield, and regulatory considerations. The video also highlights data demonstrating improvements in DNA clearance, downstream processing efficiency, and cost of goods when using nucleases optimized for process-relevant conditions.‍

Discover how rethinking your DNA clearance strategy could help improve process efficiency, product quality, and manufacturing outcomes