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WHITEPAPER: Chromatin Removal in Viral Vector Manufactu...
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Viral Bioprocessing

Whitepaper: Efficient Chromatin Removal Viral Vector Manufacturing Using Salt-Active Nucleases

Introduction

The First Enzymatic Solution for Complete Removal of Chromatin at Physiological Salt Conditions and its Effect on Downstream Processing

This whitepaper can be dowloaded in full here as a PDF and includes sections:

Abstract

Introduction

The Landscape of Salt-Active Nucleases

Comparison: Removal of Chromatin-Associated DNA in Viral Suspensions

Conclusion

References

1. Pagallies, F., Labisch, J. J., Wronska, M., Pflanz, K. & Amann, R. Efficient and scalable clarification of Orf virus from HEK suspension for vaccine development. Vaccine X 18, 100474 (2024)

2. Pereira Aguilar, P. et al. Capture and purification of Human Immunodeficiency Virus-1 virus-like particles: Convective media vs porous beads. J. Chromatogr. A 1627, 461378 (2020)

3. Mayer, V. et al. Removal of chromatin by salt‐tolerant endonucleases for production of recombinant measles virus. Biotechnol. Prog. 39, e3342 (2023)

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