Chromatin Clearance Drive Manufacturing Economics
When chromatin is not fully digested under process-relevant conditions, recovery becomes unstable and cost per dose compounds.
How Costs Compound in Downstream Processing
Reduced chromatography performance
Higher enzyme consumption
Longer processing cycles
Yield loss
Optimizing nuclease strategy is one of the fastest and lowest-risk levers to improve performance without process redesigning.
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In our viral vector manufacturing processes, ArcticZymes' M-SAN HQ and SAN HQ enzymes consistently deliver efficient host-cell DNA clearance under both physiological and high-salt conditions. This has allowed us to achieve reliable digestion with fewer nuclease units, improving process efficiency without compromising quality.
Team Lead, Viral Vector Process Development at Revvity
