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Can you truly optimize your bioprocessing without knowing THIS about DNA vs Chromatin?

The fragment problem you likely have and don't even know It
September 19, 2024 3:30 PM
September 19, 2024 4:15 PM
start-time
-
end-time
30 min presentation + Q&A

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Joint presentation with the Austrian Centre of Industrial Biotechnology (acib) 30 min j+ Q&A

What you'll learn:

  1. Understanding Chromatin vs. DNA in the context of Purification Efficiency: Explore the fundamental differences and why this knowledge is crucial for bioprocessing.
  2. Accurate Detection: Understand the importance of accurately detecting chromatin to know how much you start with and how much is removed.
  3. The Fragment Size Dilemma: Learn how improper chromatin fragmentation can lead to:
    - Inefficiencies in your workflow
    - Other issues limiting results that may not be obvious in your workflow.
  4. Enhancing Purification Processes: Learn how optimized chromatin removal can lead to more efficient downstream purification processes, reducing costs and improving product quality.
  5. Case Studies and Real-World Applications:
    - See how Salt Active Nucleases outperform conventional options like Benzonase and Denarase.
    - Discover how SAN leads to more efficient downstream purification processes, reduced costs, and improved product quality.

Who Should Attend:

  • Professionals involved in bioprocessing workflows or planning to do flow-through purification processes.
  • Anyone currently using products like Benzonase and Denarase to remove DNA from viral vectors, oncolytic viruses, or vaccines.
  • Those looking to optimize their purification processes and stay ahead in the field of bioprocessing.
  • Professionals facing challenges in chromatin fragmentation and removal, seeking practical solutions and insights.

About ArcticZymes:

ArcticZymes is the inventor Salt Active Nucleases (2015) and is the only provider of nucleases that perform optimally at both physiological and high-salt conditions. Our unique Biomanufacturing portfolio focuses on solutions that empower you to choose the nuclease that performs best, based on your conditions and your process.  Learn more about ArcticZymes: https://www.arcticzymes.com/about-us

About acib:

The Austrian Centre of Industrial Biotechnology (acib) is an international research centre in the field of industrial biotechnology. The centre develops sustainable, and economically and technologically advanced processes for the biotech-, pharmaceutical and chemical industries.

Speakers

Portrait image of Patricia Pereira Aguilar

Patricia Pereira Aguilar

Senior Scientist

Patricia Pereira Aguilar, Ph.D., is Senior Scientist at the Austrian Centre of Industial Biotechnology (acib) and affiliated to the Institute of Bioprocess Sciences and Enginnering at the BOKU University, Vienna, Austria. In 2020, she completed her Ph.D. degree in “Biomolecular Technology of Proteins” (BioTop) at BOKU, under the supervision of Professor Alois Jungbauer. After that she started working as a Postdoctoral Researcher at acib and since January 2024 as a Senior Scientist and Research Group Lead. Her research focus on the development of downstream processes and analytical tools for enveloped bionanoparticles for vaccine and gene therapy applications, such as virus-like particles, viruses and extracellular vesicles.

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Viktoria Mayer

Staff Scientist

Viktoria Mayer, M.Sc. is Staff Scientist at the Austrian Centre of Industial Biotechnology (acib), Vienna, Austria. In 2019, she completed her M.Sc. degree in Biotechnical Processes at the University of Applied Sciences in Tulln. After that she started working as a PhD student at acib which will be finished soon. Her research focuses on bionanoparticle downstream processing and analytics especially for viruses and virus-like particles.

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Portrait image of Jørn Remi Henriksen

Jørn Remi Henriksen

Sr Field Application Manager

Jørn Henriksen, Ph.D., is ArcticZymes' Sr. Field Applications Manager With a deep-rooted passion for molecular biology, his expertise isn't just academic—it's a driving force behind innovative solutions in biomanufacturing. Jørn's work bridges the gap between groundbreaking science and practical application, making the sophisticated world of enzymes accessible to researchers and manufacturers. His extensive experience, positions him as a trusted authority in the field, adept at leveraging enzymes to push the boundaries of therapeutics, including gene therapy and vaccine production.

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Can you truly optimize your bioprocessing without knowing THIS about DNA vs Chromatin?

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